| Date | Home | Away | Result |
|---|---|---|---|
| 3/22/25 1:30 PM | Cincinnati FC | Atlanta United FC | 2-2 |
| 3/22/25 3:30 PM | Minnesota United FC | Los Angeles Galaxy | 2-2 |
| 3/22/25 6:30 PM | Philadelphia Union | St. Louis City SC | 1-0 |
| 3/22/25 6:30 PM | New York Red Bulls | Toronto FC | 2-1 |
| 3/22/25 6:30 PM | Orlando City | D.C. United | 4-1 |
| 3/22/25 6:30 PM | Charlotte FC | San Jose Earthquakes | 4-1 |
| 3/22/25 6:30 PM | Columbus Crew | New York City FC | 0-0 |
| 3/22/25 7:30 PM | Sporting Kansas City | Los Angeles FC | 0-2 |
| 3/22/25 7:30 PM | Nashville SC | CF Montreal | 3-0 |
| 3/22/25 8:30 PM | Real Salt Lake | FC Dallas | 0-1 |
| 3/22/25 8:30 PM | Colorado Rapids | Portland Timbers | 0-3 |
| 3/22/25 9:30 PM | Vancouver Whitecaps | Chicago Fire | 1-3 |
| 3/22/25 9:30 PM | Seattle Sounders | Houston Dynamo | 0-0 |
| 3/23/25 3:00 PM | Austin FC | San Diego FC | 2-1 |