| Date | Home | Away | Result |
|---|---|---|---|
| 2/22/25 1:30 PM | Inter Miami CF | New York City FC | --- |
| 2/22/25 3:30 PM | Los Angeles FC | Minnesota United FC | --- |
| 2/22/25 6:30 PM | Orlando City | Philadelphia Union | --- |
| 2/22/25 6:30 PM | D.C. United | Toronto FC | --- |
| 2/22/25 6:30 PM | Columbus Crew | Chicago Fire | --- |
| 2/22/25 6:30 PM | Cincinnati FC | New York Red Bulls | --- |
| 2/22/25 6:30 PM | Atlanta United FC | CF Montreal | --- |
| 2/22/25 7:30 PM | St. Louis City SC | Colorado Rapids | --- |
| 2/22/25 7:30 PM | Nashville SC | New England Revolution | --- |
| 2/22/25 7:30 PM | Houston Dynamo | FC Dallas | --- |
| 2/22/25 7:30 PM | Austin FC | Sporting Kansas City | --- |
| 2/22/25 9:30 PM | Seattle Sounders | Charlotte FC | --- |
| 2/22/25 9:30 PM | San Jose Earthquakes | Real Salt Lake | --- |
| 2/23/25 3:00 PM | Portland Timbers | Vancouver Whitecaps | --- |
| 2/23/25 6:00 PM | Los Angeles Galaxy | San Diego FC | --- |